Welcome to Our Cape Girardeau Hotel Just off Interstate 55 at exit 96, the Holiday Inn Express® Hotel & Suites Cape Girardeau I-55 offers hotel guests 102 spacious, contemporary suites. Vacation and business guests alike choose these accommodations for a comfortable and convenient stay. Our Cape Girardeau, Missouri hotel is just minutes from Southeast Missouri State University, where guests are encouraged to cheer on the Redhawks in football and basketball. We're also only 10 miles from Trail of Tears State Park, so families can enjoy picnics, hiking, biking and fishing. Be sure to stop by the Bushyhead Memorial, as well, which commemorates those whose lives were lost on this trail in 1838. Business travelers appreciate our Cape Girardeau, Missouri hotel's convenient location close to St. Francis Hospital, Southeast Missouri Hospital, Doctors Park, the Show Me Center, Procter & Gamble, Nordenia, Shawnee Park and Biokyowa. We provide two spacious meeting rooms, as well, which feature A/V equipment ideal for business functions or special events. With the help of our professional staff, your event can be a success. At our Girardeau hotel, we know it's the extra perks that make your stay unforgettable. We provide an indoor pool and well-equipped fitness center to help you relax and unwind. Be sure to stop by our breakfast bar each morning, too, for biscuits, eggs, fruit and our signature cinnamon rolls. We look forward to your next visit!